THE DORAN LAB

University of Minnesota Twin Cities

College of Pharmacy

308 Harvard St. SE
8-125 Weaver-Densford Hall
Minneapolis, MN 55455

©2019 by The Doran Lab.

The views and opinions expressed on this page are of the page author. The contents of this page have not been reviewed or approved by the University of Minnesota

 

Publications (2018– )

23. Doran, T. M.; Nilsson, B. Incorporation of an azobenzene beta-turn peptidomimetic into amyloid-beta to probe potential structural motifs leading to beta-sheet self-assembly, Methods Mol. Biol., 2018, 1777, 387–406.

 

Publications prior to arriving at University of Minnesota Twin Cities (2010–2017)
 

22. DiMaio J. T. M., Doran T. M., Ryan D. M., Raymond D. M., Nilsson B. L. Modulating Supramolecular Peptide Hydrogel Viscoelasticity Using Biomolecular Recognition, Biomacromolecules2017, 18, 3591–3599.

21. Mendes, K; Malone, M. L.; Ndungu, J. M.; Suponitsky-Kroyter, I.; Cavett, V. J.; McEnaney, P. J.; MacConnell, A. B.; Doran, T. M.; Ronacher, K.; Stanley, K.; Utset, O.; Walzl, G.; Paegel, B. M.; Kodadek, T. High-Throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium Tuberculosis Infections, ACS Chem. Biol., 2017, 12, 234–243.

20. Doran, T. M.; Morimoto, J.; Simanski, S.; Koesema, E.; Clark, L. F.; Pels, K.; Stoops, S. L.; Pugliese, A. Skyler, J.; Kodadek, T. Discovery Of Phosphorylated Peripherin As A Major Humoral Autoantigen In Type 1 Diabetes Mellitus, Cell Chem. Biol., 2016, 23, 618–628.

 

19. Doran, T. M.; Sarkar, M.; Kodadek, T. Chemical tools to monitor and manipulate immune responses, J. Am. Chem. Soc., 2016, 138, 6076–6094.

18. Doran, T. M.; Simanski, S.; Kodadek, T. Discovery of native autoantigens via antigen surrogate technology: application to type 1 diabetes, ACS Chem. Biol. 2015, 10, 401­–412.*

                              *ACS Editors’ Choice and featured in podcast: http://ow.ly/10stLx

                              *Featured in C&EN, 2015, 92, 2, p. 5.

 

17. Doran, T. M.; Gao, Y.; Simanski, S.; MacEnaney, P. J.; Kodadek, T. High Affinity Binding of Conformationally Constrained Synthetic Oligomers to an Antigen-Specific Antibody: Discovery of a Diagnostically Useful Synthetic Ligand for Murine Type 1 Diabetes Autoantibodies, Bioorg. Med. Chem. Lett. 2015, 25, 4910–4917.

 

16. Doran, T. M.; Morimoto, J.; Simanski, S.; MacEnaney, P. J.; Kodadek, T. Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and “antigen surrogates” mounted onto a liquid array, Mol. BioSyst. 2015, 11, 3156–3163.

 

15. Doran, T. M.; Gao, Y.; Mendes, K.; Dean, S.; Simanski, S.; Kodadek, T. Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits. ACS Comb. Sci., 2014, 16, 259–270.*                                                       

                        *ACS Editors’ Choice

 

14. Doran, T. M.; Kodadek, T. A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule-Protein Interactions. ACS Chem. Biol.  2014, 9, 339–346.

 

13. Doran, T. M.; Ryan, D. M.; Nilsson, B. L., Reversible photocontrol of self-assembled peptide hydrogel viscoelasticity. Polym. Chem. 2014, 5, 241–248.

 

12. Easterhoff, D.; DiMaio, J. T. M.; Liyanage, W. N.; Lo, C.-W., Bae, W.; Doran, T. M.; Smrcka, A.; Nilsson, B. L. Dewhurst, S. Fluorescence detection of cationic amyloid fibrils in human semen. Bioorg. Med. Chem. Lett. 2013, 23, 5199–5202.

 

11. Doran, T. M.; Anderson, E. A.; Latchney S. E.; Opanashuk, L. A.; Nilsson, B. L., An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-Beta Self-Assembly. ACS Chem. Neurosci. 2012, 3, 211–220.

 

10. Doran, T. M.; Anderson, E. A.; Latchney S. E.; Opanashuk, L. A.; Nilsson, B. L., Turn Nucleation Perturbs Amyloid-b Self-Assembly and Cytotoxicity. J. Mol. Biol., 2012, 421, 315–328.

 

9. Olsen, J. S.; DiMaio, J. T. M.; Doran, T. M.; Brown, C.; Nilsson, B. L.; Dewhurst, S. Seminal Plasma Accelerates Semen-derived Enhancer of Viral Infection (SEVI) Fibril Formation by the Prostatic Acid Phosphatase (PAP248–286) Peptide. J. Biol. Chem. 2012, 287, 11842–11849.

     

8.   Doran, T. M.; Kamens, A. J.; Byrnes, N. K.; Nilsson, B. L., Role of Amino Acid Hydrophobicity, Aromaticity, and Molecular Volume on IAPP(20–29) Amyloid Self-Assembly. Proteins 2011, 80, 1053–1065.

 

7. Ryan, D. M.; Doran, T. M.; Nilsson, B. L., Complementary p-p Interactions Induce Multicomponent Co-assembly into Functional Fibrils. Langmuir 2011, 27, 11145–11156.

 

6. Ryan, D. M.; Doran, T. M.; Anderson, S. B.; Nilsson, B. L., Effect of C-Terminal Modification on the Self-Assembly and Hydrogelation of Fluorinated Fmoc-Phe Derivatives. Langmuir 201127, 4029–4039.

 

5. Easterhoff, D.; DiMaio, J. T. M.; Doran, T. M.; Dewhurst, S.; Nilsson, B. L., Enhancement of HIV-1 Infectivity by Simple, Self-Assembling Modular Peptides. Biophys. J. 2011, 100, 1325–1334.

 

4. Ryan, D. M.; Doran, T. M.; Nilsson, B. L., Stabilizing self-assembled Fmoc-F5-Phe hydrogels by co-assembly with PEG-functionalized monomers. Chem. Commun. 2011, 47, 475–477.

 

3. Senguen, F. T.; Doran, T. M.; Anderson, E. A.; Nilsson, B. L., Clarifying the influence of core amino acid hydrophobicity, secondary structure propensity, and molecular volume on amyloid-beta 16–22 self-assembly. Mol. BioSyst. 2011, 7, 497–510.

 

2. Senguen, F. T.; Lee, N. R.; Gu, X.; Ryan, D. M.; Doran, T. M.; Nilsson, B. L., Probing aromatic, hydrophobic, and steric effects on the self-assembly of an amyloid-beta fragment peptide. Mol. BioSyst. 2011, 7, 486–496.

 

1. Olsen, J. S.; Brown, C.; Capule, C. C.; Rubinshtein, M.; Doran, T. M.; Srivastava, R. K.; Feng, C.; Nilsson, B. L.; Yang, J.; Dewhurst, S., Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection. J. Biol. Chem. 2010, 285, 35488–35496.